RECOMBINA asiste al 7º Congreso Europeo de Microbiología
17 de julio de 2017
Between the 9th and 13th of July we attended the 7th Congress of European Microbiologists FEMS2017 organized in association with the 26th Congress of the Spanish Society for Microbiology (SEM) in Valencia, Spain. Below is the abstract of our poster that was displayed at the panel 017.
Novel drug discovery platform based on targeting sensory pathways of Staphylococcus aureus
Juana María Prieto1, David Viana2, José R. Penadés3, Iñigo Lasa4 and Cristina Latasa1
Biotech and pharmaceutical sectors are constantly seeking novel therapeutic approaches that might deliver us from a future where infections by resistant bacteria could pose a greater threat to human health than cancer itself. One of these strategies consists of targeting the bacterial signalling pathways known as Two Component Systems (TCSs). These systems synchronize gene expression with the different environments that bacteria might encounter, and thus regulate key biological traits as virulence or biofilm formation. Unlike the conventional antibiotics, which target essential functions, anti-TCS drugs disarm pathogens and let the immune system kill them, reducing the tendency to generate resistance and leading to less side effects towards neutral and beneficial bacteria.
1 Recombina SL. Calle Nueva 8 local 10, 31192 Mutilva, Navarra, Spain
2 Universidad Cardenal Herrera, C/ Tirant lo Blanc 7, 46115 Alfara del Patriarca, Valencia, Spain
3 Infection Immunity Inflamm, Glasgow Biomedical Research Cent, 120 University Place, Glasgow G12 8TA, Scotland.
4 Navarrabiomed-Universidad Pública de Navarra, IdiSNA, Pamplona-31008, Navarra, Spain
This project is supported by the Spanish Ministry of Economy and Competitiveness (Retos-Colaboración 2015 call)